동물 모델에서의 새로운 Brain Infusion Cannula 고정 방법

초록

Although brain infusion cannula is a good method to deliver compounds directly into thebrain, fixation of the brain infusion cannula is essential for successful delivery. Dental cementsand adhesive gel are the commonly used materials for fixation of the infusion cannula. However, these materials take time to harden and occasionally, fixation may fail. Therefore,we developed a novel method to fix the brain infusion cannula. Brain infusion cannulas wereimplanted into seven Wistar rats using the novel tie method. One, three, and seven days afterthe surgery, displacement of the brain infusion cannula and cerebrospinal fluid (CSF) leakagewere evaluated in all the rats. None of the animals showed displacement of the brain infusioncannula or leakage of CSF at any point of time. In this study, we showed the successful resultsof the novel tie method for fixation of the brain infusion cannula, which needs no additionalmaterials. It only requires a thread which is used for skin sutures.

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