Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99

Lee, Seoung Rak; Schalk, Felix; Schwitalla, Jan W.; Benndorf, René; Vollmers, John; Kaster, Anne-Kristin; Beer, Z. Wilhelm de; Park, Minji; Ahn, Mi-Jeong; Jung, Won Hee; Beemelmanns, Christine; Kim, Ki Hyun

doi:10.1021/acs.jnatprod.0c00676

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Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99

Lee, Seoung Rak;
Schalk, Felix;
Schwitalla, Jan W.;
Benndorf, René;
Vollmers, John;
... Jung, Won Hee;
외 6명

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초록

Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity. Copyright © 2020 American Chemical Society and American Society of Pharmacognosy.

키워드

NATURAL-PRODUCTS; GENISTEIN; HALOGENATION; DISCOVERY; METABOLISM; SYMBIONTS; DAIDZEIN

제목: Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99

저자: Lee, Seoung Rak; Schalk, Felix; Schwitalla, Jan W.; Benndorf, René; Vollmers, John; Kaster, Anne-Kristin; Beer, Z. Wilhelm de; Park, Minji; Ahn, Mi-Jeong; Jung, Won Hee; Beemelmanns, Christine; Kim, Ki Hyun

DOI: 10.1021/acs.jnatprod.0c00676

발행일: 2020-10

유형: Article

저널명: Journal of Natural Products

권: 83

호: 10

페이지: 3102 ~ 3110