위암에서 Claudin-4와 E-cadherin 단백 발현 감소와 임상-병리학적 인자들과의 연관성

초록

Purpose: We examined the expressions of claudin-4 and E-cadherin, which are known as cell adhesion-associated proteins, in stomach cancer. The relationship of their expression with the clinicopathologic factors was examined to investigate the roles of these proteins in the invasion or metastasis of stomach adenocarcinoma. Methods: The expressions of claudin-4 and E-cadherin were examined in 73 cases of adenocarcinoma of the stomach by performing immunohistochemical staining. Results: The expressions of claudin-4 and E-cadherin in the stomach adenocarcinoma were both correlated with the histologic grade, the T-stage and nodal metastasis, respectively (P＜0.05). The expression of claudin-4 was significantly associated with the expression of E-cadherin. Conclusion: Our data suggests that claudin-4 and E-cadherin are involved in the processes of histologic differentiation, invasion and metastasis of stomach adenocarcinoma. (J Korean Surg Soc 2007;73:221-226)

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