Steroid 5 alpha-Reductase Inhibition by Polymethoxyflavones

초록

Steroid 5 alpha-reductase inhibition was studied using eleven polymethoxyflavones (PMFs). Homologous eleven PMFs showed wide range of steroid 5 alpha-reductase inhibitory effects. Among the tested PMFs, 5-hydroxy-7,4'-dimethoxyflavone (5) was found to be the most potent inhibitor of steroid 5 alpha-reductase with the IC50 of 20 mu M. These results showed PMF's could be used as a nonsteroidal steroid 5 alpha-reductase for the treatment of benign prostatic hyperplasia.

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