Screening of Various Sources of Phytochemicals for Neuroprotective Activity against Oxygen-Glucose Deprivation in vitro

초록

Neuroprotective activities of 176 phytochemicals were investigated against oxygen-glucose deprivation in vitro using primary cortical neuron culture. Diterpenes (taxol and taxol C) were the most potent neuroprotective compounds. EC50 of taxol and taxol C were 0.402 and 0.452 mu M, respectively. This result supports the use of an in vitro model as initial screening for neuroprotective candidates, which warrants further testing in animal models.

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