Sulforaphane inhibited tumor necrosis factor-alpha induced migration and invasion in estrogen receptor negative human breast cancer cells

Bao, Cheng; Ko, Jiwon; Park, Hyun-Chang; Kim, Min Chae; Kim, Jongkee; Auh, Joong-Hyuck; Lee, Hong Jin

doi:10.1007/s10068-015-0046-7

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Sulforaphane inhibited tumor necrosis factor-alpha induced migration and invasion in estrogen receptor negative human breast cancer cells

Bao, Cheng;
Ko, Jiwon;
Park, Hyun-Chang;
Kim, Min Chae;
Kim, Jongkee;
... Auh, Joong-Hyuck;
... Lee, Hong Jin

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5

초록

Sulforaphane significantly (p < 0.05) inhibited tumor necrosis factor (TNF)-alpha induced cellular migration and invasion in MCF10DCIS.com human breast cancer cells, compared with controls. mRNA and protein expressions of MMPs, including MMP-2, MMP-9, and MMP-13, and the enzymatic activities of MMP-2 and MMP-9 were suppressed by sulforaphane treatments at 1, 5, and 10 mu M concentration in MCF10DCIS.com cells. Sulforaphane should be considered as a potent agent for retardation of mammary tumorigenesis.

키워드

breast cancer; invasion; matrix metalloproteinase; migration; sulforaphane; CARCINOMA IN-SITU; DUCTAL CARCINOMA; EXPRESSION; APOPTOSIS; ARREST; GROWTH; MMP-9

제목: Sulforaphane inhibited tumor necrosis factor-alpha induced migration and invasion in estrogen receptor negative human breast cancer cells

저자: Bao, Cheng; Ko, Jiwon; Park, Hyun-Chang; Kim, Min Chae; Kim, Jongkee; Auh, Joong-Hyuck; Lee, Hong Jin

DOI: 10.1007/s10068-015-0046-7

발행일: 2015-02

유형: Article

저널명: Food Science and Biotechnology

권: 24

호: 1

페이지: 347 ~ 351

언어: ENG

출판사: KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST

발행국가: 대한민국

분량: 5 페이지

ISSN: E 2092-6456
P 1226-7708