상세 보기
- Moon, Ji Hyun;
- Roh, Hyun-Soo;
- Park, Young Jae;
- Song, Hyun Ho;
- Choi, Jieun;
- ... Auh, Joong-Hyuck;
- ... Lee, Hong Jin;
- 외 8명
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0초록
Hepatic metabolism is an important process for evaluate the potential activity and toxicity of endocrine disrupting chemicals (EDCs) metabolites. Organization for Economic Co-operation and Development (OECD) has advocated the development of in vitro assays that mimic in vivo hepatic metabolism to eventually replace classical animal tests. In response to this need, we established a 3D mouse liver organoid (mLO) platform that mimics the animal model and is distinct from existing models. We evaluated the effects the activity of EDC metabolites generated through mLOs based on human cell-based reporter gene assays in addition to existing models. This study emphasizes the importance of hepatic ex-vivo and suggests the need a new metabolic model through a 3D mLOs platform. These results indicate that mLOs provides a novel biological method to screen for potential endocrine-disrupting activities of EDC metabolites. Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
키워드
- 제목
- A three-dimensional mouse liver organoid platform for assessing EDCs metabolites simulating liver metabolism
- 저자
- Moon, Ji Hyun; Roh, Hyun-Soo; Park, Young Jae; Song, Hyun Ho; Choi, Jieun; Jung, Da Woon; Park, Soo Jin; Park, Ho Jin; Park, So-Hyeon; Kim, Da-Eun; Kim, Gahee; Auh, Joong-Hyuck; Bhang, Dong Ha; Lee, Hong Jin; Lee, Do Yup
- 발행일
- 2025-01
- 유형
- Article
- 권
- 195